Incompatibility of Sulphonamides and Quinine

Incompatibility of Sulphonamides and Quinine

Sulphonamides and Quinine

Clinical Pharmacology of the Antimalarial Quinine in Children

Quinine is the best studied drug for treating severe malaria in very young children. Quinine may be administered in pregnancy and, at therapeutic doses, malformations have not been reported. Some strains of quinine from Southeast Asia and South America have become resistant. Quinine is the treatment of choice for the drug-resistant severe Plasmodium falciparum. The antimalarial mechanism of qui...

The fluorescence Quenching Study of Quinine in Presence of Some Anions

The quenching of quinine fluorescence intensity in the presence of some anions in aqueous solution at ambient temperature has been investigated. The quenching is found to be collisional or dynamical in nature. This study reveals the order of two groups of quencher: NaI > NaBr > NaCl > NaF and K2Cr2O7 > KMnO4 >Na2SO4 > NaClO3. Increasing anion size in the both groups leads to an  increase in the...

Intermolecular radical addition to N-acylhydrazones as a stereocontrol strategy for alkaloid synthesis: formal synthesis of quinine.

Stereocontrolled Mn-mediated radical addition of alkyl iodides to chiral N-acylhydrazones enables strategic C-C bond disconnection of chiral amines. This strategy was examined in the context of a total synthesis of quinine, generating new findings of functional group compatibility leading to a revised strategy. Completion of a formal synthesis of quinine is presented, validating the application...